Current Research Interests

Regulated RNA processing by RNA binding proteins

We have long-standing interest in the regulation of RNA metabolism, particularly with respect to the control of alternative pre-mRNA splicing in development and disease. Our initial research contributed to the establishment of the SR (for serine-arginine rich) family of splicing regulators and demonstrated that SR proteins are responsible for committing pre-mRNA to the splicing pathway. ...

Signaling mechanisms for splicing control

Our lab was also responsible for the discovery of SR protein-specific kinases (SRPKs), and demonstrated that these kinases regulate nuclear import of SR proteins and SR protein-mediated protein-protein interactions during splicing. We found that SRPKs are partitioned between the cytoplasm and the nucleus,serving as critical transducers of external signals to regulate splicing in the nucleus. ...

Regulatory RNAs and RNA binding proteins on chromatin to regulate gene expression in 3D genome

Our research has uncovered additional functions of splicing factors and regulators in gene expression at the chromatin levels, demonstrating, for example, that the classic SR protein SC35 (a.k.a. SRSF2) has a direct role in transcriptional pause release by facilitating the recruitment of the Pol II CTD kinase pTEFb, and that RBFox2 interacts with nascent ...

Cell fate determination and trans-differentiation

During our basic research of the PTB family of RNA binding proteins in regulated RNA metabolism, we unexpectedly found that depletion of PTB is able to potently convert various non-neuronal cells to neurons. Pursuing this intriguing phenomenon, we revealed that PTB suppresses a key neuronal induction pathway whereas its neuronal paralog nPTB provides a critical checkpoint ...

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We're a team that adore what we do

  • Team Member

    Xiang-dong Fu

    Distinguished Professor of CMM at UCSD

    Team Member

    Hairi Li

    Associate Project Scientist at FU's Lab

    Team Member

    Jing Hu

    Postdoctoral Fellow

  • Team Member

    Hao Qian

    Postdoctoral Fellow

    Team Member

    Lantao Gou

    Postdoctoral Fellow

    Team Member

    Changwei Shao

    Postdoctoral Fellow

    Team Member

    Dohwan Lim

    Postdoctoral Fellow

    Team Member

    Jiayu(Jerry) Chen

    Postdoctoral Fellow

    Team Member

    Fan Meng

    Postdoctoral Fellow

    Team Member

    Yajing Hao

    Postdoctoral Fellow

    Team Member

    Zhengyu Liang

    Postdoctoral Fellow

    Team Member

    Xuan Zhang

    PhD Student

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